Sulfatkonzentration im Blut gesunder Pferde nach oraler Applikation sulfathaltiger Abführmittel

Sulfatkonzentration im Blut gesunder Pferde nach oraler Applikation sulfathaltiger Abführmittel

Blood sulphate concentration in healthy horses after oral application of laxatives containing sulphur

Snyder A, Breuer B, Koeller G, Mattusch J, Abraham G, Schusser G F

DOI: 10.21836/PEM20140307
Jahr: 2014
Volume: 30
Ausgabe: 3
Seiten: 302-309

Saline laxatives are commonly used to treat colic horses with impaction of the cecum or large colon. The objective of this study was to investigate blood sulphate concentrations in healthy horses before and after orally administered sodium or magnesium sulphate. Six healthy adult fasted horses were used in a randomized study design with four treatment regimes: Trial 1: 1.8% sodium sulphate (20ml/kg BW); Trial 2: 4.2% magnesium sulphate (20ml/kg BW); Trial 3: 25% sodium sulphate (4ml/kg BW); Trial 4: 25% magnesium sulphate (4ml/kg BW). Water was used as a control (Trial 5: 20ml water/kg BW). Blood samples were taken at defined time points. The minimal and maximal value of serum sulphate concentration in healthy fasted horses was 0.29 and 0.42mmol/l. Sulphate concentrations increased moderately, statistically significant (P<0.05) in Trial 1 (0.66±0.12mmol/l after 90min) and Trial 2 (0.57±0.11mmol/l after 150min), and severely (P ≤ 0.001) in Trial 3 (1.37±0.26mmol/l after 240min) and Trial 4 (1.01±0.22mmol/l after 240min) compared to pretest values (Trial 1: 0.29±0.15mmol/l; Trial 2: 0.32±0.06mmol/l; Trial 3: 0.39±0.06mmol/l; Trial 4: 0.39±0.02 mmol/l). There was no increase in the sulphate concentrations in the control group (Trial 5: 0.42±0.04mmol/l). We conclude that a single dose of orally administered isotonic sodium or magnesium sulphate increases serum sulphate concentrations moderately, whereas hypertonic sodium or magnesium sulphate increases serum sulphate concentrations greatly in normal horses without clinical signs of adverse reactions.